2009-10: Brandon DeFazio was second in points and penalty minutes for Clarkson University as a junior. He scored 12 goals with 14 assists in 35 games for the Golden Knights (12 points behind scoring leader Matt Beca) and had 58 penalty minutes (Tim Marks finished with 70). The Golden Knights finished last in ECAC Hockey; winning nine games during the season.
2010-11: DeFazio made his pro hockey debut — playing for the Wilkes-Barre/Scranton Penguins and playing a key role for in the ECHL playoffs for Wheeling — after leading Clarkson University in scoring as a senior. He had no points nor penalties in two AHL games with the Penguins. In ten regular season games with Wheeling he scored 4 goals with 5 assists and was plus-five with 7 penalty minutes. The Nailers reached the Eastern Conference finals and DeFazio scored 4 goals with 2 assist and was minus-five with 8 penalty minutes in 14 playoff games. He scored a career-high 14 goals with 12 assists and was minus-seven with 58 penalty minutes in 36 games during his final college season with the Golden Knights; with 5 of his 12 goals coming on the power play.
2011-12: DeFazio was invited to Pittsburgh's training camp and signed an AHL contract with Wilkes-Barre/Scranton. Playing primarily in a physical, energy line role, he scored 11 goals with 5 assists in 66 games and he was second on the Penguins with 104 penalty minutes. Wilkes-Barre/Scranton reached the second round in the playoffs after finishing second in the East Division and DeFazio was an even plus/minus with no points and 6 penalty minutes in 12 playoff games. He signed a one-year, entry-level contract with the Islanders in July, 2012.
2012-13: DeFazio skated in career-high 69 games for the Islanders' AHL affiliate in Bridgeport in his second pro season. He scored 11 goals with 14 assists and was -3 with 139 penalty minutes. The Sound Tigers missed the AHL playoffs after finishing third in the Northeast Division. DeFazio was signed by Vancouver to one-year contract as an unrestricted free agent in July of 2013.
DeFazio signed with the Vancouver Canucks in July, 2013.