2010-11: Brendan Perlini skated for the Belle Tire bantam AAA team in suburban Detroit after playing his youth hockey in his hometown of Sault Ste. Marie, Ontario. He scored 18 goals with 17 assists and had 17 penalty minutes in 31 games.
2011-12: Perlini was the second-leading scorer for the Belle Tire U16 midget team. He scored 21 goals with 23 assists and had 20 penalty minutes in 40 regular season games. Belle Tire finished first in the Tier 1 Elite league's Great Lakes Division Perlini scored 4 goals with 3 assists in seven playoff games. He was selected by the Barrie Colts in the first round (16th overall) of the 2012 OHL Priority Draft.
2012-13: Perlini began his first OHL season with Barrie before being obtained by Central Division rival Niagara in January in a mid-season trade. He scored 1 goal with 1 assist and was -6 with 4 penalty minutes in 32 games in limited ice time with the first-place Colts before the trade to the fourth-place IceDogs. He scored 7 goals with 3 assists and was -15 with 4 penalty minutes in 27 games with Niagara. The IceDogs reached the playoffs despite finishing under .500 and Perlini scored 1 goal with 2 assists and 4 penalty minutes in the five game series with Oshawa.
2013-14: Perlini attended Hockey Canada's U18 camp before returning to Niagara for his first full season with the IceDogs.