2010-11: Brent Pedersen played for the Waterloo Wolves midget minor AAA team in Ontario. He scored 34 goals with 18 assists in 49 games. He scored 9 goals with 8 assists and 2 penalty minutes in 13 playoff games. Pedersen was selected by Kitchener in the first round (14th overall) of the 2011 OHL Priority Draft.
2011-12: Pedersen played 65 games for Kitchener in his first OHL season and skated for Canada Ontario in the 2012 U17 World Hockey Challenge. He scored 9 goals with 5 assists and was -10 with 12 penalty minutes for the Rangers. Kitchener finished second to OHL champion London in the Midwest Division and reached the conference finals. Pedersen played in all 16 playoff games, finishing +1 with 1 assist. Playing for bronze medal-winning Canada Ontario he scored 2 goals with 2 assists in six games at the WHC.
2012-13: Pedersen, playing on a line with fellow 1995-born prospects Justin Bailey and Josh Sterk, provided secondary scoring and two-way play in his second season for Kitchener. He scored 14 goals with 16 assists in 67 games and was +11 with 52 penalty minutes. Kitchener finished third in the Midwest Division and lost to Memorial Cup-bound London in the second round of the playoffs. Pedersen played in eight playoff games, missing the final two games after suffering an injury in Game 3 against London. He was -3 with no points and 2 penalty minutes in the playoffs. Pedersen was ranked 125th amongst North American skaters in Central Scouting's final rankings and was selected by Carolina in the fifth round (126th overall) of the 2013 NHL Draft.