2008-09: Matt Mangene played 43 games for the New Hampshire Junior Monarchs in his second season in the Eastern Junior Hockey League. He scored 12 goals with 25 assists and had 39 penalty minutes. The Monarchs captured USA Hockey's U-20 national championship. Mangene committed to playing college hockey at the University of Maine.
2009-10: Mangene played in 29 games for Maine as a freshman, missing ten games due to an injury. He scored 1 goal with 10 assists and was minus-four with 10 penalty minutes. Maine turned things around after starting 1-5 to finish fourth in Hockey East. The Black Bears reached the Hockey East championship game – falling to eventual Frozen Four champion Boston College in a wild 7-6 overtime game.
2010-11: Mangene appeared in all 36 games for Maine as a sophomore. He scored 3 goals with 7 assists and was minus-five with 42 penalty minutes. Maine slipped to fifth in Hockey East and was swept by Merrimack in the playoff quarterfinals.
2011-12: Mangene made his pro hockey debut with Flyers AHL affiliate Adirondack and signed a two-year entry-level contract with Philadelphia in March 2012 following his junior season at Maine. He was scoreless with no penalties in five games for the Phantoms, who finished fifth in the Northeast Division and missed the AHL playoffs. Shifting from defense to the wing in early December, he scored 16 goals with 18 assists and had 58 penalty minutes in 40 games during the college season. Maine reached the Hockey East championship game for the second time in three years (and again lost to eventual national champion BC) and earned the school's first NCAA tournament berth since 2006-07.
2012-13: Mangene played 36 games for the Flyers' AHL affiliate in Adirondack in his first pro season and also skated for the ECHL's Trenton Titans. The odd-man-out at times in the first half due to the presence of several NHL forwards during the lockout, he appeared in just four games with the Phantoms (all in October) and was loaned to Trenton. He saw more consistent time with Adirondack following the lockout, scoring 5 goals with 6 assists, and was – 8 with 8 penalty minutes. The Phantoms missed the playoffs after finishing last in the Northeast Division. A converted defenseman, Mangene played both forward and defense for the short-handed Titans and had 6 assists in 14 games; finishing -11 with 23 penalty minutes.
Mangene is playing for the AHL's Adirondack Phantoms in 2013-14. He is now a forward rather than a defenseman, with the switch appearing to be a permanent one.
Mangene was dealt by the Philadelphia Flyers to the New York Islanders in the deal that sent Andrew MacDonald to the Flyers in March of 2014.