2006-07: Nikita Nikitin enjoyed a strong campaign in the Russian Super League. He put up 15 assists with Avangard Omsk, also scoring a goal, and was plus-8 with 99 PIM on the second-place club. Avangard made it to the semi-finals in the playoffs before falling to Matallurg. Nikitin continued to provide offensive production with five assists in 11 games. He also recorded 39 minutes in penalties.
2007-08: Continuing his Russian hockey career with Avangard Omsk (RSL), the defenseman notched three goals and 14 points in 57 games this season.
2008-09: Nikitin was the second-leading scorer among defensemen for Omsk Avangard in Russia's re-christened KHL as a 22-year-old. In 53 games he scored 4 goals with 12 assists and was +7 with 28 PMs as Omsk finished in the middle-of-the-pack in the 24-team league. In nine playoff games he scored 1 goal with 2 assists and 8 PMs.
2009-10: Limited to 43 games in his fifth season with Omsk, Nikitin scored 4 goals with 9 assists and was -3 with 14 PMs. Avangard finished second in the Chernyshev Division but was eliminated in the first round of the playoffs. In three playoff games Nikitin was scoreless with an even plus/minus. Nikitin signed a one-year, entry-level contract with St. Louis in June 2010.
2010-11: Nikitin made his NHL debut with St. Louis in November 2011 and appeared in 41 games with the Blues; missing time with a wrist injury and also skating for AHL Peoria. Nikitin scored 1 goal with 8 assists and was +1 with 10 PMs; averaging 16:23 minutes of ice time per game with St. Louis. In 22 games with Peoria he scored 3 goals with 11 assists and was +1 with 12 PMs. He scored all three of his goals for the Rivermen on the power play. He did not play in Peoria's four-game playoff series with Houston. Nikitin signed a one-year contract extension with the Blues in June 2011.
Nikitin is a strong skater, which enables him to play the role of puck-moving defenseman. His shot is hard, and he can make crisp break-out passes in his own zone. He doesn’t shy away from physicality.
Nikitin was dealt from the St. Louis Blues to the Columbus Blue Jackets in November, 2011.